In Introduction to Christianity, Ratzinger characterizes the evolution of the modern world view through the use of a careful distinction between emphasis on "what we have made" -- factum -- to "what we can make" -- faciendum -- by means of the human ability to make -- techne. Factum is the historical approach, the understanding of who and what we are by the understanding of how we got here, essentially the evolutionary approach. Our ability to manipulate what we are is the faciendum, what we might call the transhumanist or cybernetic approach, which takes the evolutionary approach as a given and looks beyond it. (To illustrate, he quotes Marx: "So far philosophers have contemplated the world; now they must set about changing it.")
It might be a little disorienting to think of factum as "what we have made" rather than simply as "fact." What he means is not so much our artifacts as our ability to perceive, define, and make sense out of the world in the process of manipulating it.